Activation of human monocyte cell line U937 via cell surface calreticulin

Jang-Hyun Cho; Koichi J. Homma; Shiro Kanegasaki; Shunji Natori

doi:10.1379/1466-1268(2001)006<0148:AOHMCL>2.0.CO;2

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Jang-Hyun Cho,¹ Koichi J. Homma,² Shiro Kanegasaki,³ Shunji Natori¹

¹aNatori Special Laboratory, Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako-
²bGraduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo 113-
³cEffector Cell Institute, Research Center for Advanced Science and Technology, University of Tokyo,

Abstract

U937 cells were found to be activated by an antibacterial peptide, KLKLLLLLKLK-NH₂ (L5), to generate superoxide anion (O₂⁻)-like peripheral neutrophils. However, the state of cell surface calreticulin, a possible receptor for L5, was suggested to differ between neutrophils and U937 cells. Unlike the former, the latter ones were activated by anti-C-domain peptide antibody of calreticulin even in the absence of L5 and generated O₂⁻ in a GTP-binding protein (G-protein)-dependent manner.

Citation Download Citation

Jang-Hyun Cho, Koichi J. Homma, Shiro Kanegasaki, and Shunji Natori "Activation of human monocyte cell line U937 via cell surface calreticulin," Cell Stress & Chaperones 6(2), 148-152, (1 April 2001). https://doi.org/10.1379/1466-1268(2001)006<0148:AOHMCL>2.0.CO;2

Received: 4 September 2000; Accepted: 1 January 2001; Published: 1 April 2001

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